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1. If injections were given for three or more months to these osteogenic sarcomas, 85% survived four-40 years later (4).
   [ 4. Nauts, H.C.: Osteogenic sarcoma: end results following immunotherapy (bacterial vaccines) 165 cases, or concurrent infections, inflammation or fever, 41 cases. Cancer Research Institute, Monograph #15. New York, 1975. ]
   
   
2. Calkins of Watertown, New York, gave the injections daily for about six months, then twice weekly with occasional intervals of rest for another six months. (12) Injections were given as an outpatient after the first two weeks. Calkins achieved 80% five-year survival in using this technique over a 32 year period.
   [ 12. Nauts, H.C.: Beneficial effects of acute concurrent infection, inflammation, fever or immunotherapy (bacterial toxins) on ovarian and uterine cancer. Cancer Research Institute. Monograph #17. New York, 1977. (122 pp.) and conference with Calkins 1943 ]
   
   
3. As to the frequency of injection he said: "In the absence of excessive reaction or great debility, the injections may be given daily, with the expectation of obtaining two or three well marked reactions during the week. With the occurrence of marked diminution in the growth, frequency may be diminished." Fowler believed that the injections should be kept up 3 or 4 months, with occasional intervals of rest lasting 3 or 4 days.
   [ The Treatment of Malignant Tumors by Bacterial Toxins as Developed by the Late William B. Coley, M.D., Reviewed in the Light of Modern Research ]

Note: I just reviewed the historical analysis of Coley's Toxins efficacy on the MBVax website and decided that I should refer you there for now. When I obtain Helen Coley Nauts' monographs, I intend to verify MBVax' analysis (for those described in her monographs).