Curcumin for cancer

  • Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer
    Two patients (out of 25) showed clinical biological activity. One had ongoing stable disease for >18 months; interestingly, one additional patient had a brief, but marked, tumor regression (73%) accompanied by significant increases (4- to 35-fold) in serum cytokine levels.
    "There is still not a scientific consensus on how those with active cancer may best take advantage of the multiple potential benefits of curcumin. Most cancer patients have been taking 1800 to 3600 mg a day of curcumin. Life Extension has recommended that curcumin not be combined with the chemotherapy drug Camptosar (irinotecan) because of one animal study that indicated a possible adverse effect. Since curcumin has not been adequately tested with other chemotherapy drugs, it might be safe to wait until chemotherapy is completed before initiating curcumin. Cancer patients using curcumin may want to avoid high doses of "thiol" nutrients such as cysteine, lipoic acid, SAMe and glutathione because these nutrients might interfere with curcumin's PKC inhibiting effects in actively growing cancer. Since thiol compounds are critically important anti-aging nutrients, cancer patients may consider avoiding or reducing thiol nutrients for a three to six month period while consuming high doses of curcumin (along with soy, green tea extracts, I3C and other nutrients that have shown specific anti-cancer effects)."

  • It seems the main problem with Curcumin is absorption. Apparently, mixing with fat and adding piperine (from pepper) improves absorption. Will we see liposomal formulations soon? I've been giving my wife the same formulation used in Dr. Aggarwal's clinical trials (Curcumin C3).
  • Pretty good CBS news video that talks about the benefits of curcumin