Evidence linking fevers/infections with tumor regression

Throughout history, physicians have observed and documented the clear links between infection and regression of cancer. In a significant number of cases, the regression is not just temporary but lasts for decades (essentially what we call a "cure"). Dr. William Coley was certainly not the first to have encountered this seemingly miraculous effect. He was certainly bitten by the "coley bug" when he personally tracked down Mr. Zola and verified that the impossible had occurred. 
 
This dramatic, and seemingly miraculous effect, is real.

Coley's Toxins IV #11 - Breaking tolerance

Today, we increased the dosage from 0.004ml -> 0.006ml. We did this because it was becoming apparent that her body is developing tolerance to Coley's Toxins. We felt that increasing to 0.005 wouldn't do too much based on previous fever curves.

Coley's Toxins IV #10 - Still not good enough

Today's dosage was again an increase to 0.004ml. This was because last Friday's fever wasn't very high and maxed out at 102.4F for a short duration.

Today's was even lower. It maxed out at 101.9F and for not very long either. I would estimate that the average fever was about 101F. It wasn't very difficult to tolerate and recovery as the fever subsided was very quick.

Coley's Toxins Week 3

SAM 4137This week I had two increases in dosage - to 0.002mL and 0.003mL. Neither dosages gave me sustained fever above 102.5F. Most likely I'm developing some tolerance, so there will be more dose escalation next week.

Coley's Toxins IV #9 - A better fever but could be higher. A lingering (but very infrequent) cough.

Today we increased dosage again to 0.003ml. The fever was uneventful and predictable. It was somewhat better than the last one. However, it wasn't as high as we'd hoped for. The peak was a tad below the desired 102.5F threshold. So we'll need to increase again next Monday.

Coley's Toxins IV #8 - Another sub-optimal fever at 0.002mL

SAM 4100After some deliberation, we decided not to increase the dose level. Instead, we wanted to see if a higher fever could be obtained by increasing external heat instead. After all, we felt that the previous fever (#7) was quite a good one, despite the sub-optimal temperature. It's duration was long and she was quite fatigued after that fever.

Coley's Toxins: Optimal treatment duration & corresponding survival rates

The student of Coley's Toxins will know that the successful complete remission of cancer via Coley's Toxins is not a simple thing to achieve logistically. Unlike simple infusions or oral ingestion of drugs that directly attack cancer, Coley's Toxins seeks to modify the incredibly complex immune system. I get quite disappointed whenever I hear simplistic declarations of how the immune system works.

Coley's Toxins IV #7 - A long but sub-optimal fever

Today's fever was uneventful but interesting. We went with an increased dose of 0.002ml thinking that an increase from 0.00075ml to 0.001ml wouldn't do much. We were right.

The chills began 1 hour after infusion start like clockwork. However, 3 hours after infusion start, her temperature was still 101.2F. It became apparent that today's was not going to a very high fever.

The fever stayed mostly between 101 and 102F for a good 3 hours. It briefly touched 102.5F but only for a few minutes.

Coley's Toxins Weeks 1 & 2

SAM 3830We had heard and read much about Coley's Toxins and its potential side effects, and now I was to experience it. We want to share my experience with others: how Coley's Toxins actually makes one feel - both immediately during and after treatment. The past two weeks have been like a long experiment. We recorded every sensation I felt during and after the Coley's treatment.

Coley's Toxins IV #6 - Looks like it's time to increase dosage more aggressively

Coley's Toxins treatment: Waiting for feverToday, it took almost 2 hours before there was any rise in temperature at all. However, she eventually developed fever, although it was clear that the temperature rise was not as fast and as high as previous treatments. She also experienced some light chills at that time.